Definium Therapeutics
DT120 · LSD (lysergide d-tartrate) · Generalized Anxiety Disorder
Company Overview
Definium Therapeutics (formerly MindMed, rebranded January 9, 2026) is a clinical-stage biopharmaceutical company developing psychedelic-inspired therapies. Their lead program DT120 (formerly MM120), a pharmaceutical-grade d-tartrate salt of LSD, received FDA Breakthrough Therapy Designation for Generalized Anxiety Disorder. DT120 Phase 2b was completed and published in JAMA in October 2025. Four Phase 3 trials are enrolling or planned: Voyage (GAD, topline Q2 2026), Panorama (GAD, topline H2 2026), Emerge (MDD, topline mid-2026), and ASCEND (second MDD study, ~175 participants, planned mid-2026). Definium is one of the best-capitalized companies in the psychedelic space.
Pipeline
| Drug / Compound | Stage | Indication |
|---|---|---|
DT120 LSD d-tartrate (lysergide d-tartrate) | Phase 3 | Generalized Anxiety Disorder |
DT120 LSD d-tartrate (lysergide d-tartrate) | Phase 3 | Major Depressive Disorder |
DT120 LSD d-tartrate (lysergide d-tartrate) | Phase 3 | Major Depressive Disorder |
DT402 R-MDMA (rectus enantiomer of MDMA) | Phase 2a | Autism Spectrum Disorder |
Key Financials
- Cash Position
- $412M
- Burn Rate
- ~$20-40M/quarter
- Last Reported
- Q3 2025
Financial data is approximate. Always verify with official SEC filings.
Upcoming Catalysts
- Q2 2026Voyage Phase 3 topline readout for DT120 in Generalized Anxiety DisorderClinical
- Mid-2026Emerge Phase 3 topline readout for DT120 in Major Depressive DisorderClinical
- H2 2026Panorama Phase 3 topline readout for DT120 in Generalized Anxiety DisorderClinical
- Mid-2026ASCEND Phase 3 trial initiation for DT120 in MDD (~175 participants)Clinical
Recent News
- 2026-01MindMed rebrands as Definium Therapeutics, trades as DFTX; four Phase 3 DT120 trials enrolling or planned
- 2025-10MindMed MM120 Phase 2b results published in JAMA, showing durable GAD response
News items are manually curated from public company press releases.
External Links
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Disclaimer: This page is for informational purposes only and does not constitute investment, medical, or financial advice. Pipeline status, financial figures, and catalyst dates are approximate and based on publicly available information as of 2026-02-25. Always consult official company filings and a qualified financial advisor before making investment decisions.