Ketamine Therapy Cost in Colorado

47 providers across 22 cities

Colorado has a thriving psychedelic therapy landscape with 32+ ketamine providers and a growing number of psilocybin healing centers. Colorado is one of three states with legal pathways for psilocybin therapy — Proposition 122 passed in November 2022, establishing the Regulated Natural Medicine Access Program for supervised psilocybin therapy through licensed healing centers. Licensed healing centers began operating in 2025. Patients in Colorado have access to a broader range of evidence-based psychedelic treatments than in almost any other state, from IV ketamine infusions to regulated psilocybin-assisted therapy sessions.

Modalities Available

Colorado clinics offer IV ketamine infusion, intramuscular (IM) ketamine, Spravato at certified REMS centers, oral/sublingual ketamine, and ketamine-assisted psychotherapy (KAP). Klarisana, a Colorado-based provider and one of the largest IM ketamine providers in the country, specializes in IM delivery. Additionally, Colorado's Natural Medicine program allows licensed healing centers to administer psilocybin-assisted therapy to adults 21 and older — a legal option available in very few other states.

Cost & Pricing

Ketamine therapy in Colorado typically ranges from $285–$515 per session based on verified provider data. IV ketamine infusions run $400–$515, while IM ketamine — offered by providers like Klarisana — is often lower at $285–$400 per session. Spravato retail medication costs run $882–$1,663 per dose depending on strength, plus $300–$700+ in mandatory observation fees. With the J&J withMe Savings Program, eligible commercially insured patients may pay as little as $10 per session total. Psilocybin therapy through licensed healing centers costs $1,500–$3,500+ per session, with some centers offering sliding scale pricing starting as low as $1,000. All psilocybin therapy is out-of-pocket.

Insurance Coverage

Most ketamine therapy in Colorado is paid out-of-pocket. Spravato is covered by most major commercial insurers, Medicare, and Medicaid after prior authorization. With the J&J withMe Savings Program, eligible commercially insured patients may pay as little as $10 per session; without it, coinsurance can be substantially higher. Psilocybin therapy is entirely out-of-pocket — Colorado law explicitly states no insurer is required to cover natural medicine. Many clinics accept HSA and FSA payments. Klarisana accepts Colorado Medicaid for IM ketamine, which is uncommon in the industry.

Psilocybin Therapy in Colorado

Following Proposition 122 in November 2022, Colorado established the Regulated Natural Medicine Access Program. Licensed healing centers began operating in 2025 — The Center Origin in Denver received the first license in March 2025, followed by centers in Boulder and Fort Collins. Sessions include preparation, supervised psilocybin administration, and integration therapy. This is a regulated, legal option for adults 21 and older seeking an alternative or complement to ketamine therapy.

Conditions Treated

Colorado clinics treat treatment-resistant depression, anxiety, PTSD, OCD, chronic pain, and suicidal ideation. The addition of legal psilocybin therapy expands treatment options particularly for patients who have not responded to ketamine or traditional medications. The combination of both treatment modalities available in the same state gives Colorado one of the most comprehensive psychedelic medicine landscapes in the country.

Frequently Asked Questions

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